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	Provedor de dados J. Venom. Anim. Toxins incl. Trop. Dis. (2) Autor Carrieri,M. L. (2) Consales,C. A. (2) Achkar,S. M. (1) Ceretta,R. S. (1) Galina,N. M. F. (1) Passos,E. C. (1) Pereira,C. A. (1) Ribeiro,O. G. (1) Sant'Anna,O. A. (1) Sinhorini,I. L. (1) Mais... Palavra-chave Rabies (2) Immunoglobulin isotypes (1) Infection (1) Inflammation (1) Isotypes (1) Nervous system (1) Pathology (1) Virus replication (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2007 (1) 2006 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Immunopathology of rabies infection in mice selected for high or low acute inflammatory reaction J. Venom. Anim. Toxins incl. Trop. Dis. Achkar,S. M.; Sinhorini,I. L.; Ribeiro,O. G.; Carrieri,M. L.; Ceretta,R. S.; Consales,C. A.. Rabies is a severe and lethal disease that produces a slight inflammatory response during the infection process. We analyzed the immunopathological mechanisms that occur in the central nervous system (CNS) using mice genetically selected for maximal or minimal acute inflammatory reaction (AIRmax or AIRmin). As viral samples, we adopted the antigenic variant 3 (AgV3) of rabies virus from hematophagous bats and a fixed virus strain (PV1 43/3). Titration of specific antibodies was performed using enzyme-linked immunosorbent assay (ELISA). We observed a slight increase in IgG and IgG1 isotypes in infected AIRmax mice. Incubation period, determined by intracerebral inoculation with 100 LD50, was 6-7 days for PV1 43/4 strain and 9-10 days for AgV3. No difference... Tipo: Info:eu-repo/semantics/article Palavras-chave: Rabies; Virus replication; Pathology; Inflammation; Immunoglobulin isotypes. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000100003 Lack of correlation between rabies virus replication in the brain and antibody isotype profile in genetically modified mice J. Venom. Anim. Toxins incl. Trop. Dis. Consales,C. A.; Pereira,C. A.; Passos,E. C.; Carrieri,M. L.; Galina,N. M. F.; Sant'Anna,O. A.. The relationship among the phenotypes resistance to infection, virus replication in the brain and isotype production was investigated in genetically modified High (H) or Low (L) antibody responder mouse lines. Although they express the same innate susceptibility to rabies infection, these lines differ as to different viral replication rates in the central nervous system and L mice showed a higher permissible state. After intramuscular infection with the Pasteur rabies strain (PV), the H-L interline differences on the earlier stage of virus replication were 1000 and 80 folds on days 5 and 6, respectively. The isotype profile in sera of the experimentally infected mice reflected an interline difference of 25 folds for IgG2a throughout the infection period,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Rabies; Infection; Isotypes; Nervous system. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000300007 Registros recuperados: 2 Primeira ... 1 ... Última

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